Hyperbaric oxygen therapy may alleviate symptoms of Alzheimer’s Disease
A new study reveals that hyperbaric oxygen treatments may ameliorate symptoms experienced by patients with Alzheimer’s disease. In this study, the subjects who undergo hyperbaric oxygen therapy for different conditions breathe in pure oxygen in a pressurized room or chamber. In this chamber, the air pressure is increased to twice that of normal air. Under these conditions, oxygen solubility in the blood increases and is transported by blood vessels throughout the body. The added oxygen stimulates the release of growth factors and stem cells, which themselves promote healing.
Ronit Shapira, Beka Solomon, Shai Efrati, Dan Frenkel, Uri Ashery. Hyperbaric oxygen therapy ameliorates pathophysiology of 3xTg-AD mouse model by attenuating neuroinflammation. Neurobiology of Aging, 2018; 62: 105 DOI: 10.1016/j.neurobiolaging.2017.10.007
Watch What Alzheimer’s Does to The Brain!
(Video Credit: Alzheimer’s Disease Education and Referral Centre)
High quality diets reduces the risk of dementia: A new strategy.
A Canadian study shows the direct link between a healthy diet that is rich in vegetables, fruits, nuts, whole grains, and fish but contains little amount of high-fat dairy products, sweets, processed foods and red meat and the reduced risk of dementia.
Greenwood CE and Parrott MD. Nutrition as a component of dementia risk reduction strategies. Healthc Manage Forum. 2017 Jan;30(1):40-45. doi: 10.1177/0840470416662885.
Traumatic brain injury increases the risk of Alzheimer’s later in the life
The epidemiological studies suggest that adults with a history of moderate-to-severe t(but not mild) traumatic brain injury (TBI) may have an increased risk for developing neurodegenerative disease, such as Alzheimer’s later in their life.
Raj R. et al, Risk of hospitalization with neurodegenerative disease after moderate-to-severe traumatic brain injury in the working-age population: A retrospective cohort study using the Finnish national health registries. PLoS Med. 2017 Jul; 14(7): e1002316. doi: 10.1371/journal.pmed.1002316
Spectroscopy, a simple diagnostic test for Alzheimer’s Disease.
A new screening test has been introduced by the scientists from University of Central Lancashire. Currently, there is no accurate and early diagnostic test available for neurodegenerative disorders such as Alzheimer’s disease. Using blood plasma, this study introduces a blood test by spectroscopy to provide a robust and sensitive diagnostic test with higher specificity than clinical and molecular techniques.
Paraskevaidi M. et al. Differential diagnosis of Alzheimer’s disease using spectrochemical analysis of blood. Proc Natl Acad Sci U S A. 2017 Sep 5. pii: 201701517. doi: 10.1073/pnas.1701517114.
Midlife cardiovascular risk factors may increase chances of dementia
Source: NIH/National Institute of Neurological Disorders and Stroke
A study that was published in JAMA Neurology, has shown a link between cardiovascular risk factors such as high blood pressure, diabetes and smoking, with dementia.
The researcher at Johns Hopkins University (lead researcher Professor Rebecca Gottesman) discovered a link between dementia. Also, Diabetes, hypertension and smoking cigarettes increased the chances of dementia in the participants of this study.
Gottesman et al. Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. JAMA Neurology, August 7, 2017 DOI: 10.1001/jamaneurol.2017.1658
Alzheimer’s and Parkinson’s Overlapped Toxicity Mechanisms: A Review of the Shared Pathological Mechanisms
Source: National Center for Biotechnology Information (NCBI)
A Biomedical Central Article has reviewed the interaction between two main neurodegenerative disorders in humans, Alzheimer’s and Parkinson’s diseases. Dr. Shohreh Majd from Flinedrs University has explained the shared cellular mechanisms associate to the pathology of Alzheimer’s and Prkinson’s, the first two neurodegenerative disorders in humans. The shared molecular and cellular mechanisms are responsible for some similar clinical presentations in patients. The article is focused on protein toxicity in Alzheimer’s and Parkinson’s diseases and the activated mechanisms of neurotoxicity in response to misfolded beta-amyloid and α-synuclein, two major toxic proteins in the mentioned disorders, leading to brain cells’ death.
Majd et al. Neuronal response in Alzheimer’s and Parkinson’s disease: the effect of toxic proteins on intracellular pathways. BMC Neurosci Oct 23, 2015 DOI:10.1186/s12868-015-0211-1